I’ve been letting a lot of dumb shit slide by recently, but this is just too bluntly moronic to repel comment. The gist of the article:
Dr. Evans and his team found that PPAR-delta remodels the muscle, producing more of the high endurance type of fiber. They genetically engineered a strain of mice whose muscles produced extra amounts of PPAR-delta. These mice grew more Type 1 fibers and could run twice as far as on a treadmill as ordinary mice before collapsing.
Given that people cannot be improved in this way, Dr. Evans wondered if levels of the gene-controlling protein could be raised by drugs. Pharmaceutical companies have long tried to manipulate the protein because of its role in fat metabolism, and Dr. Evans found several drugs were already available, although they had been tested for different purposes.
The original tagline blares that this is the advent of getting a “workout in a pill” - a dangerously imprecise interpretation. The drugs, if they work, function by stimulating muscle growth in the absence of a stimulus from actual training (or non-recreational exertion). Now, there are at least two problems with this process, both of which should be sufficient reasons to reject a “workout-replacement” role for the drugs. First, at least according to Steven Vogel, the endurance gains humans achieve in performing aerobic activity are associated with muscle growth only with respect to the heart muscle. As a glance at any cross-country team will confirm, endurance sports do not require and do not develop much growth in fibers of any kind in skeletal muscle. Even if drugs can induce growth in human skeletal muscle, it is not clear that significant gains in endurance will follow.
It is one thing to say a drug won’t work; a much louder alert should be sounded when a drug carries the risk of imparting serious injury to its user. That, I believe, would be the case with any “muscle-growth-in-a-pill” regimen. Even doped-up bodybuilders, “roided out to their mutant gills,” combine the assisting chemicals with actual training, which - pay attention - stimulates the central nervous system as well as any muscles involved. When nothing is done to attune the CNS to handling an increased muscle mass (and with it, increased force), the potential for injury grows. The point is familiar to anyone who has stuck with a weight training program long enough to experience so-called “beginner gains,” increases in strength coming from CNS adaptation and preceding any significant muscle growth. In a hypothetical example, an untrained and sedentary adult will move more weight on any exercise (or the same weight for additional repetitions) after four weeks of progressive training; the same person put on a (theoretically effective) drug regimen and barred from exercising will not only probably move the same amount of weight four weeks in, but would also be more likely to sustain an injury, given the higher forces operating at an untrained level of coordination on muscles, tendons, and other tissue. Medication for muscle growth, viewed in this light, may be not only undesirable for untrained patients, but even counterproductive. A complete “workout in a pill” should include, at minimum, effects on muscle composition and neural development paralleling those of an actual exercise routine. It is the latter component, every bit as important as the former, that has been omitted by the researchers profiled in the linked article.